Day Four
Wednesday, November 7, 2018
Session 23: The Morning After? Politics, Policy & What Just Happened
Session 24: Augmenting Biology and Reversing Aging
24.1 Andrew Pelling Scientist & Founder, Pelling Lab
24.2 Amy Wagers PhD Professor of Stem Cell and Regenerative Biology, Harvard University
Pioneering Longevity with Peter H. Diamandis & Bob Hariri
Peter Diamandis MD Executive Founder and Director, Singularity University, Founder and Executive Chairman, XPRIZE Foundation
Bob Hariri, MD, MPH Founder, Chairman & CEO, Celularity
David Karow MD PhD CEO, Human Longevity Inc
Osman Kibar PhD CEO, Samumed
Art and Medicine with Andrew Paul Leonard
Session 26: Crystal Ball: Creating the Future of Healthcare
Janet Foutty Chair and CEO, Deloitte Consulting
Doug Beaudoin Principal, Life Sciences & Healthcare, Deloitte
Pat Combes Worldwide Technical Leader, Healthcare & Life Sciences, Amazon Web Services
Diane Hammon Vice President and Chief Strategy Officer, Moffitt Cancer Center
Session 27: Democratizing Technology for Global Health
David Bray PhD Impact & Disruption Faculty, Singularity University, Executive Director, People-Centered Internet, President, Hu-manity.org
Peter M. Small, MD Rockefeller Fellow
Alex Kumar MBBS Global Health Physician, NHS National Institute for Health Research
Ralph Simon FSRA Chief Executive, Mobilium Global
Session 28: Converting Insights into Action: What Happened at xMed. What Does This Mean? What's Next?
Tom Wujec Founder, The Wujec Group
Will Weisman Executive Director, Summits, Singularity University
Daniel Kraft MD Faculty Chair for Medicine, Singularity University and Founder & Chair, Exponential Medicine
Session 23
The Morning After? Politics, Policy & What Just Happened
Peter:
Intellectual property and capital does not respect political boundaries.
Where you start your company may be influenced by the political and legal surroundings. We don’t want to run good companies out of the country.
Education of children:
- Very little of what is in current education is unusable in real life
- Critically important to help children find their passion
- Important to help people ask great questions…because now finding the answer may be easier than knowing what the right question is to ask.
- Grit - persistance
Session 24
Augmenting Biology and Reversing Aging
24.1 Andrew Pelling
Scientist & Founder, Pelling Lab
Field of mechanobiology - how do cells sense, and generate their own mechanical forces. The genome can be regulated by physical features (eg. stretch). Every stage of development of an embryo can be influenced by mechanical forces.
There is an important relationship between the physical world and how the genome is expressed. If we focus just on the DNA part, we actually loose an important part of the picture.
However, exactly what the relationship between physical world and genome expression is, remains to be discovered.
At rest cells are naturally undergoing certain amounts of stretch.
cellular In some of their experiments the behaviour of cells dramatically changes - they become aggressively metastatic - when stretch is introduced into cellular model.
How do cells sense shape? Yes, they spatially pattern over areas
How can we create bio-scafolds, that may be used for regenerative medicine and tissue engineering? Can we use a material such as ‘plans’ as the bio-scafold?
Experiment involved taking piece of apple, stripping out all the cells (decellularization), and one is left only with the extracellular matrix. Surpassingly, when cells were applied, they grew in it well.
Bough apples, carved them into shape of ears. Decellularization process. And grew human cells on them. Below early image of scafold.
Question - are the materials safe in a body? They placed the human-cell-apple-scafold after it had been cultured into a mouse, and under the microscope health innervation of mouse cells and blood vessels was seen.
Note: no stem cells. No growth factors.
Lab’s focus at this time: bone, soft tissue cartilage, spinal cord and nerve repair
His lab: be curious, be rigorous, have a diverse group of people
24.2 Amy Wagers
PhD Professor of Stem Cell and Regenerative Biology, Harvard University
Uses technique of Parabiosis - which is joining together (aka side/by/side) mice. Join together young/young, young/old, and old/old combinations. Can see the effect of having old/young cells on how they influence each other.
Changes in different cell markers and predict outcomes, and modulation of them can effect lifespans.
Specifically GDF11
Pioneering Longevity with Peter H. Diamandis & Bob Hariri
Peter Diamandis
MD Executive Founder and Director, Singularity University, Founder and Executive Chairman, XPRIZE Foundation
“The comment, I don’t want to know what’s going on inside my body, is bullshit”
‘If we can add an extra 10 to 20 years of productive lifespan, that influences government, and society dramatically’
Bob Hariri
MD, MPH Founder, Chairman & CEO, Celularity
Health concerns of aging including: chronic diseases, frailty and loss of activities of daily living, cognitive decline.
Placenta cells do not need to be matched to the individual, and they do not induce a rejection response.
David Karow
MD PhD CEO, Human Longevity Inc
3000 people total have gone through Health Nucleus.
Dramatic drop in the cost since opening in 2015. Current cost is $5,000 for first visit, and $3000 for subsequent. [Which is below the actual cost]
Osman Kibar
PhD CEO, Samumed
$13 billion dollar private company.
Restorative Medicine company. [Doing out of this world work.]
Repair the Wnt pathway.
Examples - note: these are in human clinical trials
Also have program to regenerate hair, remove wrinkles, to remove scarring in the lungs (fibrosis). [These are all in human clinical trials].
It’s a spare parts business. You replace the part that is worn out.
The cartilage cells in the knee is different than cartilage cells nose. This means they are aware of their local surroundings and exactly what type of cartilage they are to develop.
They have dosed over 1000 patients, and have not noticed a single adverse drug event. The drug is designed that it is inert of the Wht pathway is intact.
It is not just about anti-aging - because that is only stoping aging. They are de-aging, because they are able to reverse the aging process.
How is this done?
Embryonic stem cells -> progenitor stem cells -> adult cells
The embryonic stem cells only function inside the fetus/embryo
The Progenitor stem cells (eg. dermal stem cells, epithelial stem cells, mesenchymal stem cells), remain in the body tissues, and replenish our adult cells (eg. bone, cartilage, hair, skin, etc) as we live.
The Wnt pathway regulates the differentiation from progenitor to adult stem cells.
Note: the Wnt pathway is the same across all animal species.
As we age, the Wnt pathway becomes out of balance, and this leads to under/over production of adult cells leading to disease and aging.
They develop drugs they move the Wnt levels into the healthy range for that adult cell type.
Daniel Kraft
Art and Medicine
with Andrew Paul Leonard
Session 26
Crystal Ball: Creating the Future of Healthcare
Janet Foutty Chair and CEO, Deloitte Consulting
Doug Beaudoin Principal, Life Sciences & Healthcare, Deloitte
Pat Combes Worldwide Technical Leader, Healthcare & Life Sciences, Amazon Web Services
Diane Hammon Vice President and Chief Strategy Officer, Moffitt Cancer Center
Session 27
Democratizing Technology for Global Health
Ralph Simon
FSRA Chief Executive, Mobilium Global
Peter M. Small
MD Rockefeller Fellow
The global health mafia will not disrupt itself.
Alex Kumar
MBBS Global Health Physician, NHS National Institute for Health Research
Global Health Security Agenda
- Antimicrobial resistance (AMR)
- Water and food scarcity
- Climate Change
- Outbreaks
- homo sapiens
David Bray
PhD Impact & Disruption Faculty, Singularity University, Executive Director, People-Centered Internet, President, Hu-manity.org
Personalized medicine can also be personalized poison.
We may be living in an area where we move from being organized by geography, to being organized by networks.
When we are organized by geography ideas have a bell curve with opposite positions on either side.
When organized by networks, like forms with like, and we get amplification of extremes and loss of the middle.
Session 28:
Converting Insights into Action:
What Happened at xMed. What Does This Mean? What's Next?
Tom Wujec Founder, The Wujec Group
Will Weisman Executive Director, Summits, Singularity University
Daniel Kraft MD Faculty Chair for Medicine, Singularity University and Founder & Chair, Exponential Medicine
All slides are from the Singularity University’s Exponential Medicine Conference YouTube live stream November 7, 2018.
Watch past Singularity University videos on their channel.
To register for next year’s conference, please visit their website, https://exponential.singularityu.org/medicine/ It sells outs, so register early.
You may be interested in the Notes from Day 1, or Notes from Day 2, Notes from Day 3,